When a Mux (multiplexer) /De-Mux (demultiplexer) -type bus switch is used for differential signaling, is the I/O terminal of the bus switch specified for directionality, such as dedicated TX, RX?

The bus switch is bidirectional mux/de-mux, so there is no directional specification for the I/O pins.

Fig. 1 Example of use as Mux
Fig. 1 Example of use as Mux

The bus switch is a passive switch, and the I/O pins are electrically connected to the internal switch.
Therefore, it can be used as a Mux (Fig. 1) /De-Mux (Fig. 2) regardless of TX/RX.

Fig. 2 Example of use as De-Mux
Fig. 2 Example of use as De-Mux

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